General Information

  • ID:  hor005210
  • Uniprot ID:  P09196
  • Protein name:  Natriuretic peptides A
  • Gene name:  NA
  • Organism:  Pelophylax ridibundus (Marsh frog) (Rana ridibunda)
  • Family:  natriuretic peptide family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pelophylax (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006182 cGMP biosynthetic process; GO:0007168 receptor guanylyl cyclase signaling pathway; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SMRRSSDCFGSRIDRIGAQSGMGCGRF
  • Length:  27(4-30)
  • Propeptide:  APRSMRRSSDCFGSRIDRIGAQSGMGCGRF
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Has a cGMP-stimulating activity .
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  45893
  • Structure ID:  AF-P09196-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005210_AF2.pdbhor005210_ESM.pdb

Physical Information

Mass: 340225 Formula: C117H193N43O38S4
Absent amino acids: EHKLNPTVWY Common amino acids: GRS
pI: 10.41 Basic residues: 5
Polar residues: 12 Hydrophobic residues: 5
Hydrophobicity: -51.11 Boman Index: -8501
Half-Life / Aliphatic Index: 1.9 hour Aliphatic Index: 32.59
Instability Index: 6892.96 Extinction Coefficient cystines: 125
Absorbance 280nm: 4.81

Literature

  • PubMed ID:  2971573
  • Title:  The amino acid sequences of frog heart atrial natriuretic-like peptide and mammalian ANF are closely related.